化工新型材料

化工新型材料 ›› 2021, Vol. 49 ›› Issue (9) : 250-254. DOI: 10.19817/j.cnki.issn 1006-3536.2021.09.054

开发与应用

PCL-PEG-PCL微球制备及释药性研究

作者信息 +

Research on the preparation and drug release of PCL-PEG-PCL microspheres

Cai Jiehui, Lu Jinjuan, Zheng Yanfei

Author information +

文章历史 +

Received		Published
2020-05-20		2021-09-20
Issue Date	Revised Date
2021-09-30	2020-05-20

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摘要

采用开环聚合法制备了聚己内酯-聚乙二醇-聚己内酯(PCL-PEG-PCL)共聚物,再采用水包油包水(W₁/O/W₂)复乳法制备载姜黄素PCL-PEG-PCL微球,研究载药微球释药行为。通过红外光谱(FT-IR)、热重分析仪、扫描电镜(SEM)等技术对其组成及结构进行表征。FT-IR结果表明PEG接枝上PCL;SEM结果表明微球形貌圆整;粒度分析表明粒径范围在6.3～10.3μm;热分析结果表明在30～60℃内微球存在相变过程;体外释药结果表明微球对药物具有缓释功能,释药机制以扩散为主,微球外部骨架溶蚀为辅。

Abstract

PCL-PEG-PCL polymers were prepared by ring-opening polymerization.Curcumin-loaded PCL-PEG-PCL microspheres were prepared by W₁/O/W₂ double emulsion method.The drug release behavior of drug-loaded microspheres were studied.The composition of the copolymers were characterized by FT-IR,TGA,SME analysis technology.FT-IR results showed that the copolymers contained the segments of PCL and PEG.SEM confirmed that the structure of the microsphere were round.Particle size analysis showed that the particle size ranges from 6.3～10.3μm.The results of thermal analysis showed that it's a phase transition process at 30～60℃.In vitro release results shown that PCL-PEG-PCL microspheres had sustained-release effect on Cur.The mechanism of drug release was mainly diffusion,supplemented by the dissolution of the external skeleton of the microspheres.

关键词

聚己内酯-聚乙二醇-聚己内酯 / 姜黄素 / 载药微球 / 体外释放

Key words

PCL-PEG-PCL / curcumin / durg-loaded microsphere / in vitro drug release

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PCL-PEG-PCL微球制备及释药性研究[J]. 化工新型材料, 2021, 49(9): 250-254 DOI:10.19817/j.cnki.issn 1006-3536.2021.09.054

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